Prion Disease is currently an invariably fatal condition without treatment or cure. Despite multiple prior treatment studies, including quinacrine, doxycycline, and pentosan polysulfate, no ...

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60%.

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent.

Further research is needed to take CHARM to clinical trials, but the rapid development so far has shown significant promise for the treatment of prion diseases in the near future.

Prion diseases are characterized by abnormal folding of the ... such as alleviating suffering by improving the understanding, prevention, and treatment of illnesses. “She really goes out of her way to ...

Jan. 14, 2025 — Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition.

Context: Fatal familial insomnia (FFI) is a genetically transmitted neurodegenerative prion disease that incurs great suffering and has neither a treatment nor a cure. The clinical literature is ...

Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition. The treatment ...