In fact, an estimated 90% to 95% of people with CML have the Ph chromosome, which contains BCR-ABL1. Although less common, BCR-ABL1 can also be present in other types of leukemia. These include ...

[32] These hematologic "remissions" are characterized by persistence of Ph-positive cells in the marrow, with inevitable progression to blast crisis. Suppression of Philadelphia chromosome ...

Discovery of the Philadelphia (Ph) chromosome in 1960 paved the way to identification of BCR/ABL as the principal genetic ...

This trend continued until the duo began to work with patients with CML. At this time, Hungerford noticed an atypical small chromosome in cancer cells from two patients with this disease.

Kolibaba, KS, Druker BJ. Current Status of Treatment for Chronic Myelogenous Leukemia. MedGenMed 2(2), 2000 [formerly published in Medscape Hematology-Oncology eJournal 3(2), 2000]. Available at ...