Liver cirrhosis is a dangerous disease to have, and patients with liver cirrhosis develop swelling of the abdomen due to fluid accumulation, known as ascites, and may also experience pedal edema.

A 31-year-old man taking methadone 500 mg twice daily as part of a detoxification program developed bilateral and pedal edema with a 27-kg weight gain. [35] The patient did not have concomitant ...