Phase 1 data for Spyre Therapeutics, Inc.'s SPY002 & SPY072 show promise in autoimmune treatments. Advancing to Phase 2 ...

Inflammatory bowel diseases (IBDs), such as Crohn's disease or ulcerative colitis, arise when there is a dysregulation of cell signalling pathways, leading to a chronic inflammatory response.

The funding will support the development of a new therapeutic approach in IBD focusing on the TREM-1 pathway. The funding follows a R&D collaboration between Inotrem, and the Crohn’s & Colitis ...

Specific protein signatures could predict a future diagnosis of Crohn disease and ulcerative colitis, potentially enabling ...

Genes in the interleukin-23–Th17 pathway that have been associated with Crohn's disease are designated by red stars, and those with ulcerative colitis by blue stars. The initial immune response ...

Researchers have discovered a new biological pathway that is a principal driver ... the umbrella term for Crohn's disease and ulcerative colitis. These diseases are also becoming more common ...

et al. “TWEAK/Fn14 Is Overexpressed in Crohn’s Disease and Mediates Experimental Ileitis by Regulating Critical Innate and Adaptive Immune Pathways.” Cellular and Molecular Gastroenterology and ...

In recent studies using the Dextran Sulfate Sodium (DSS) colitis mouse model, PALI-2108 demonstrated a dose-dependent effect on key fibrotic pathways, underscoring its potential as an effective ...

The two main types of IBD are known as ulcerative colitis and Crohn’s disease ... “Using genetics as a starting point, we’ve uncovered a pathway that appears to play a major role in IBD ...

A study led by biomedical scientists at the University of California, Riverside School of Medicine shows how a genetic ...