Several hallmarks of ageing could contribute to OA: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction ...

Furthermore, we now appreciate that OA pathogenesis involves not only breakdown of cartilage, but also remodelling of the underlying bone, formation of ectopic bone, hypertrophy of the joint ...

Over the past decade, there has been a significant shift in the conceptualization of osteoarthritis etiology and pathogenesis. Sometimes oversimplified as the rejection of an old-fashioned “wear ...

Unfortunately, the same is not true for OA, where current pharmacologic treatment focuses on symptomatic relief. This article not only highlights the differences in the pathophysiology and ...

“This study provides novel insights into the pathogenesis of OA and suggests a potential therapeutic target in OA treatment.” The concept of osteoarthritis (OA) as a low-grade inflammatory ...

As highlighted in recent advances in rheumatoid arthritis pathogenesis, researchers’ understanding of the disease has grown considerably in recent years, laying the groundwork for new ...

1 The cause of rheumatoid arthritis is unknown, and the prognosis is guarded. However, advances in understanding the pathogenesis of the disease have fostered the development of new therapeutics ...

However, the cell heterogeneity of chondrocytes in human articular cartilage is still not well defined, which hinders understanding of the pathogenesis of OA. This research, published in the Genes ...

Wang and colleagues concluded that the complement cascade is a crucial element in the pathogenesis of OA and that targeting the complement system may lead to disease-modifying therapy for OA.

However, the cell heterogeneity of chondrocytes in human articular cartilage is still not well defined, which hinders understanding of the pathogenesis of OA. This research, published in the Genes ...

Osteoarthritis (OA) is a joint disease affecting the entire joint, including the cartilage, bone, and joint lining. Lifestyle factors, age, joint injury, and genetics can all contribute to OA and ...