The concept of an intrinsic regenerative capacity of the adult mammalian myocardium owing to the presence of cardiac stem cells (CSCs ... is mediated by a paracrine–autocrine feedback loop ...

Cardiac stem ... of paracrine factors released by MSCs. These factors can enhance angiogenesis (the formation of new blood vessels), reduce cell death, and improve overall heart function[3].

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In 27 June Nature, Hans-Peter Gerber and colleagues from Genentech Inc., San Francisco, show that VEGF regulates haematopoietic stem cell (HSC) survival by an internal autocrine loop mechanism (Nature ...

The functional autocrine loop constituted by coexpression of the KIT receptor tyrosine kinase (TK) and its ligand stem cell factor was first reported in small-cell lung cancer (SCLC) tumors and ...

The inhibitory mechanism of action comes from the ability of these DC secreted CTLA-4+ EVs to bind to the co-stimulatory DC surface markers CD80 and CD86 to prevent T-cell activation. Therefore DC ...