The study, published in Science Signaling, highlights the protein tyrosine phosphatase PTP1B, a nodal enzyme involved in insulin signaling, as a key driver in maladaptive cardiac metabolism and ...

Blocking PTP1B in heart cells may stop heart failure linked to high-fat diets and obesity. (CREDIT: Kontaridis Lab)© The Brighter Side of News PTP1B in the heart functions as a metabolic switch.

Sun, Y., et al. (2025) Deletion of PTP1B in cardiomyocytes alters cardiac metabolic signaling to protect against cardiomyopathy induced by a high-fat diet.