Transcriptionally repressive histone H3 lysine 27 methylation by Polycomb repressive complex 2 (PRC2) is essential for cellular differentiation and development. Here we report cryo–electron microscopy ...

The study is the first to define, at the molecular level, how RNA regulates PRC2 activity and could pave the way for more effective, targeted treatments for diseases where PRC2 regulation is defective ...

ORIC’s clinical stage product candidates include (1) ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and ...

CU Boulder scientists have captured unprecedented images revealing how RNA and the gene-silencing complex PRC2 do their job. The findings could pave the way for a new generation of cancer drugs.