Studies of pRB and E2F function in flies and worms share some important similarities that provide insight into the core activities of these proteins and show how a common regulatory module can ...

RNA interference experiments reveal that induction of Noxa, and subsequent cell death, rely not only on the transcription factor E2F-1 but also on its regulator pRb. In response to ABT-737 ...

and resulting in the E2F-mediated stimulation of genes involved in the G1 → S transition. The E7 proteins of high-and low-risk HPV strains share a specific amino acid difference in their pRb ...

The product of this tumor suppressor gene, a 105-kilodalton polypeptide called pRB, `is a cell cycle regulator. The pRB polypeptide inhibits cell proliferation by arresting cells at the G1 phase of ...

In this regard, the functional interaction between pRB and the E2F transcription factor family appears to be critical. The pRB-E2F interaction is, in turn, regulated by a pathway that includes cyclin ...

In this form, pRB binds to various downstream effectors, including E2F transcription factors, which are thus unable to activate target genes required for DNA replication. In contrast, pRB–E2F ...