Restoration of AKT activation using pharmacological agonists in PP2A-deficient CD8+ T cells partially rescued their effector functions, suggesting a critical role for the PP2A-AKT axis in T cell ...

Loss of PP2A function has previously been linked to induction of cancer. The researchers showed that PP2A activation resulted in modulation of expression of key molecules that regulate cell ...

Protein phosphatase 2A (PP2A) is a heterotrimer affecting approximately 60% of all serine/threonine phosphorylations. PP2A functions as a tumor suppressor when it is a trimer (PP2A-A-PP2Ac-B56) ...

Dongwei Yuan, Shun Zhou, Suning Liu, Kang Li, Haigang Zhao, Shihui Long, Hanhan Liu, Yongfang Xie, Yunlin Su, Fengwei Yu, Sheng Li, The AMPK-PP2A axis in insect fat body is activated by ...