Proper activation of protein phosphatase 2A (PP2A) catalytic subunit is central for the complex PP2A regulation and is crucial for broad aspects of cellular function. The crystal structure of PP2A ...

In a research article published in SCIENCE CHINA Life Sciences, Yao et al. uncovered a previously unknown p53-SET-PP2A regulatory feedback loop and raised a potential strategy for cancer therapy ...

Collectively, this study describes a new fundamental mechanism of gene expression regulation and demonstrates that concomitant CDK9 inhibition and PP2A activation results in enhanced anti-cancer ...

Dongwei Yuan, Shun Zhou, Suning Liu, Kang Li, Haigang Zhao, Shihui Long, Hanhan Liu, Yongfang Xie, Yunlin Su, Fengwei Yu, Sheng Li, The AMPK-PP2A axis in insect fat body is activated by ...

Results: No differences were observed in PP2A/C expression according to gender, smoking history, PS, type of EGFR mutation, or other clinical characteristics. Overall response rate (RR) was 70%, ...

Researchers from Atux Iskay LLC presented data from a study that aimed to assess whether reactivation of protein phosphatase 2A (PP2A) using a small-molecule PP2A activator, ATUX-1215, could counter ...