In a research article published in SCIENCE CHINA Life Sciences, Yao et al. uncovered a previously unknown p53-SET-PP2A regulatory feedback loop and raised a potential strategy for cancer therapy ...

Collectively, this study describes a new fundamental mechanism of gene expression regulation and demonstrates that concomitant CDK9 inhibition and PP2A activation results in enhanced anti-cancer ...

Dongwei Yuan, Shun Zhou, Suning Liu, Kang Li, Haigang Zhao, Shihui Long, Hanhan Liu, Yongfang Xie, Yunlin Su, Fengwei Yu, Sheng Li, The AMPK-PP2A axis in insect fat body is activated by ...

Researchers from Atux Iskay LLC presented data from a study that aimed to assess whether reactivation of protein phosphatase 2A (PP2A) using a small-molecule PP2A activator, ATUX-1215, could counter ...

Results: No differences were observed in PP2A/C expression according to gender, smoking history, PS, type of EGFR mutation, or other clinical characteristics. Overall response rate (RR) was 70%, ...