34 Collectively, these findings indicate that lncRNAs function as key regulators of CSC glycolysis. In the present study, we explored the role and regulation of PDK1 in BCSCs and found that PDK1 ...

The expression levels of genes associated with glycolysis, c-MYC, GLUT1, LDHA, HIF1A and pyruvate dehydrogenase kinase-1 (PDK1) were determined by real-time PCR. Glucose consumption and lactate ...

This led to a decrease in PDHA1 S293 phosphorylation and an increase in PDH enzyme activity, promoting oxidative ...

This led to a decrease in PDHA1 S293 phosphorylation and an increase in PDH enzyme activity, promoting oxidative phosphorylation and reducing glycolysis. The clinical relevance of PDK1 Y163 ...

the PDK1 enzyme prevents the pyruvate from entering the mitochondrion (the organelle in charge of the cell energy production) as a metabolic fuel for cell glycolysis. The altered metabolic pathway ...

This led to a decrease in PDHA1 S293 phosphorylation and an increase in PDH enzyme activity, promoting oxidative phosphorylation and reducing glycolysis. The clinical relevance of PDK1 Y163 ...

the PDK1 enzyme prevents the pyruvate from entering the mitochondrion (the organelle in charge of the cell energy production) as a metabolic fuel for cell glycolysis. The altered metabolic pathway ...

In order to complete their life cycle within the cell and to produce the next generation of viruses, the viruses depend on the activity of a specific cellular enzyme called PDK1 kinase.