In this study, we provide further evidence that PDK-1 is upregulated in hypoxia and that it is under the control of the HIF-1 transcription factor in HNSCC cell lines and many other cancer cell types.

Here, we report that AKT phosphorylation is elevated in both RMS tissue samples and cell lines. Interference of AKT signalling pathway with OSU-03012, a small molecule compound targeting PDK-1 ...