Mice with an extra copy of the gene known as Pten didn't get cancer, but that's not the half of it. Those mice were also leaner, even as they ate more than controls, Serrano said. That suggested ...

The Pten-deficient mice had elevated white blood cells counts, consistent with leukemia. The Shp2-deficient mice experienced the opposite -- lower white blood cell counts.

We will cover mice exhibiting complete and constitutive inactivation of Pten as well as a large number of strains in which Pten has been conditionally deleted in specific tissues. We hope to ...

2000; Marsh et al. 1997). Other data hinted that PTEN also plays a role in neurodevelopment, but conventional knockout mice die before embryonic day 9. Now, Xin Liu, Hong Wu, and colleagues at ...

Researchers first deleted PTEN from tumor cells grown in cell culture and from tumors in mice, and found an increase in the number cells able to form new tumors, which suggests that PTEN ...

Our laboratory is interested in the use of mouse models of prostate cancer to explore the pathogenesis of prostate cancer and its response to treatment. We have used the SV-40 based TRAMP model of ...

which reported that the authors examined whether the TSGs Rb1, Trp53, Pten, and Men1 have cooperative effects in suppressing neuroendocrine tumors in mice. By monitoring growth and examining the ...

Researchers first deleted PTEN from tumor cells grown in cell culture and from tumors in mice, and found an increase in the number cells able to form new tumors, which suggests that PTEN ...