The molecular basis is not known. Osteoprotegerin deficiency could explain juvenile Paget's disease because osteoprotegerin suppresses bone turnover by functioning as a decoy receptor for ...

OPG and RANKL Are Regulated by Systemic Hormones, Growth Factors, and Cytokines Cite this: Osteoprotegerin and its Ligand: A New Paradigm for Regulation of Osteoclastogenesis and Bone Resorption ...

Osteoprotegerin is a protein that is involved in the pathogenesis of diabetic foot. OBJECTIVES The aim of the study was to evaluate the frequency of alleles in the TNFRSF11B gene rs2073617, rs2073618, ...

INTRODUCTION Calcific aortic valve disease is associated with inflammation and calcification, thus the osteoprotegerin (OPG), receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) ...

Previous research has suggested that factor VIII (FVIII) can regulate the osteoprotegerin (OPG)/RANKL system, which appears to play a role in hemophilic arthropathy. Investigators have now aimed to ...

Recombinant osteoprotegerin, given as a once-weekly, self-administered subcutaneous injection, could be a valuable treatment for this serious disorder, as perhaps could be the recently developed ...

Led first by the discovery of osteoprotegerin (OPG), a naturally occurring protein with potent osteoclastogenesis inhibitory activity, rapid progress was made to the isolation of RANKL ...