Researchers from Kyoto University and Kyushu University have created human oogonia out of stem cells. Oogonia are small diploid cells that form during the early stages of fetal development.

Primordial germ cells, which emerge around day 16 in early human embryos, develop to form oogonia so that eventually, the number of oocytes that are present in an adult female is fixed at birth.

More information: Chika Yamashiro et al. Generation of human oogonia from induced pluripotent stem cells in vitro, Science (2018). DOI: 10.1126/science.aat1674 Journal information: Science ...

Dr. Mitinori Saitou, Kyoto University Remarkably, these hPGCLC-derived mitotic pro-spermatogonia/oogonia not only displayed similarities in gene expression and epigenetic profiles to that of ...

In six to 10 weeks after fertilization, PGCs differentiate into pro-spermatogonia and oogonia, which are precursors to sperm and eggs, respectively. Mitinori Saitou, a professor of cell biology ...

“Here, we show that hPGCLCs differentiate progressively into oogonia-like cells during a long-term in vitro culture (~four months) in xenogeneic reconstituted ovaries with mouse embryonic ...

Researchers produced the immature egg cells (seen in pink) out of stem cells created using human blood Saitou Labs A team of Japanese researchers has successfully created oogonia, or primitive ...