Less than a month after researchers unveiled that a “ticking DNA clock” is behind Huntington’s disease (HD), scientists have ...

With its recent data drop for an oligonucleotide candidate, Dyne Therapeutics signals it may become a frontrunner in this ...

Oligonucleotide probes are short stretches of single-stranded DNA or RNA used to detect the presence of complementary nucleic acid sequences (target sequences) by hybridization. Oligonucleotide ...

The technical aspects involved with the design, synthesis and use of oligonucleotide arrays for gene expression experiments are now fairly routine. New breakthroughs will require careful ...

(5) Chemicals cleave the oligonucleotide and remove protecting groups. (6) Continued exposure to harsh chemicals damages the DNA and reduces yields. Scientists use short oligonucleotides as primers ...

Preclinical studies have shown their potential to reduce inflammation and modulate immune responses in diseases like rheumatoid arthritis and lupus.

Direct chemical synthesis has been adapted to make oligonucleotides of remarkable length, including an 800 nucleotide green ...

Therapeutic synthetic oligonucleotides face unique analytical challenges in late-stage development. Meeting stringent regulatory requirements demands highly specific and sensitive methods like LC-MS.

Over recent years, there has been an increasing number of approved oligonucleotide-based therapies, but widespread use of the drug has been limited in part because of difficulties in its manufacturing ...

With the rapid increase in the development of oligonucleotide therapeutics and gene therapies ... High-resolution time-of-flight mass spectrometry (TOF-MS) can be used for this analysis offering ...