Although the technique reliably produces iPSCs, cellular reprogramming with the four Yamanaka factors—Oct4, Sox2, Klf4, and cMyc (collectively known as OSKM)—remains inefficient and incomplete, and it ...

The protocol relies on overexpressing the so-called Yamanaka factors, which are four transcription factors: Oct4, Sox2, Klf4, and cMyc (OSKM). While the technique reliably creates iPS cells, it can ...

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We found that overexpression of one of these factors, Oct4, causes epigenetic changes that deteriorate the quality of the resultant iPSCs. Excluding Oct4 from the reprogramming cocktail leads to iPSCs ...