In normal bone, OPG interferes with the binding of RANKL to RANK by acting as a decoy receptor for RANKL (Figure 2; also reviewed in reference 22) and thereby prevents excessive bone destruction ...

OPG is a secreted decoy receptor for RANKL and functions as the physiological inhibitor of RANK–RANKL signaling (Figure 3). [ 10 , 18 ] Thus, the ratio of RANKL to OPG expressed by osteoblasts ...

Future Oncol. 2013;9(11):1609-1622. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the ...

The OPG/RANKL ratio is considered a key regulator of bone metabolism. We recently found that in osteoarthritic subchondral bone osteoblasts, OPG and RANKL are altered when compared to normal. 3.

Background: The activity of the receptor activator of nuclear factor-kβ RANK/RANKL in cancer cells has been correlated with tumor progression and poor prognosis in solid tumors including bladder ...

Panel B shows the effect of OPG on the mean level of RANKL-stimulated NF-κB activation of the human embryonic-kidney cell line HEK293. Cells were incubated in various combinations of a vehicle ...

Baseline RANK, RANKL and OPG median values were 78.3 (range 7.3-620.6), 319.1 (21.4-1884.4) and 1.52 (0.1-58.0), respectively. At 12 months RANKL median value had decreased by 22% with respect to ...

Conclusions The role of RANK/RANKL/OPG pathway in both bone/musculo-skeletal and cardiovascular metabolism has rather recently been studied. The possible positive influence of exercise on this pathway ...