Credit: 2022, Takaya Ishihara, Mitochondrial nucleoid trafficking regulated by the inner-membrane AAA-ATPase ATAD3A modulates respiratory complex formation, Proceedings of the National Academy of ...

Nucleoid-associated proteins (NAPs) bind to the bacterial chromosome and alter its dynamics, maintaining nucleoid structure. In this Review, Dillon and Dorman examine the range of proteins in the ...

New insights into mitochondrial nucleoid dynamics Researchers led by Osaka University find that a molecule called ATAD3A is essential for the movement of genetic material inside mitochondria ...

Ishihara, T., et al. (2022) Mitochondrial nucleoid trafficking regulated by the inner-membrane AAA-ATPase ATAD3A modulates respiratory complex formation.

However, unlike the nucleus, the nucleoid constantly undergoes structural changes. The chromosomes within the prokaryotes are also found in the form of small molecules of DNA called plasmids.

“Nucleoid trafficking may represent a new therapeutic target to prevent mitochondrial dysfunction in various human diseases,” explains senior author Naotada Ishihara. Therefore, not only does this ...