Nearly a third of HIV-positive patients with kidney impairment received incorrect prescriptions for nucleoside reverse transcript inhibitors (NRTIs) at a university-based clinic in the United States, ...

They cite evidence for the association of higher intracellular NRTI phosphate levels with severity of HIV disease. A few studies also suggest that women have higher concentrations of phosphorylated ...

For patients with HIV-1 RNA levels of less than 100,000 copies per milliliter at screening, the NRTI-sparing group had a longer time to virologic failure than the lopinavir–ritonavir group (P=0. ...

NRTI-resistance Mutations & their Mechanism of Drug Resistance In 1989, drug-resistant HIV-1 was isolated from patients treated with zidovudine, [33,34] leading to identification of the first ...

Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years. Although HAART can ...

In a non-peer-reviewed interim analysis of a comparison of 3 PI-sparing regimens for treatment-naive patients, researchers found a significantly higher rate of virologic failure in the triple-NRTI ...

Existing high-quality evidence shows the durability of regimens consisting of protease inhibitors with NRTIs in the public health approach, even in the context of NRTI resistance. 4,25 ...