persistence of neurofibrillary tangles and neuropil threads in areas devoid of plaques; and third, extensive macrophage infiltration of cerebral white matter. Uncertainty remains over the conseque ...

Diffuse and neuritic plaques of Aβ deposited in extracellular spaces Hyperphosphorylated tau protein aggregated into neurofibrillary tangles and threads inside neurons Amyloid-beta is released by ...

New serine biomarkers show promise for early Alzheimer's detection, linking tau assemblies to cognitive decline and offering potential for timely intervention.