In their report published online in Genes & Development, the team describes finding how mutations in the NF2 (neurofibromatosis type 2) gene, which codes for the merlin protein, make cells hyper ...

Neurofibromatosis type 2 is caused by a change in the NF2 gene located on chromosome 22. This gene encodes a protein known as merlin. Mutations in the NF2 gene disrupt the function of merlin, which is ...

There is a 50 percent chance that a child born to parents with NF1 or NF2 will inherit the gene and develop NF1 or NF2. This is known as an autosomal dominant inheritance pattern. Tumors in this ...

The mutation in the gene means that the nerve tissue is not properly controlled. There are three types: Nf1, Nf2, and schwannomatosis. They are not related. This article will focus mainly on Nf1 ...

Recursion discovered REC-2282 as a potential candidate for treatment of disease resulting from mutation in the NF2 gene by leveraging its proprietary AI-powered drug discovery platform ...

Meningiomas, often linked to the loss of the NF2 gene, are a hallmark of NF2-SWN and can severely impact patients' lives despite being typically non-malignant. Through this new project ...

progressive genetic condition in which people are born with only one normal copy of the NF2 gene, Plotkin explained. For that reason they are predisposed to multiple tumors -- as well as multiple ...

It occurs due to a variation in either the TSC1 or TSC2 gene. Neurofibromatosis refers to three different conditions. These conditions are neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and ...

attracted their attention because it is characterized by the loss of a copy of the NF2 gene, which plays a role in tumor-suppression. When NF2 is missing, meningiomas proliferate, typically affecting ...

Key events in mesothelioma tumorigenesis encompass inactivation of the neurofibromatosis gene type 2 (NF2) and loss of INK4α/ARF, but other molecular mechanisms cannot be excluded. Inactivation ...