Neurofibromatosis type 2 is caused by a change in the NF2 gene located on chromosome 22. This gene encodes a protein known as merlin. Mutations in the NF2 gene disrupt the function of merlin, which is ...

Neurofibromatosis is a rare disease with the estimation of around one in 3,000 people living with this condition. However, that does not mean that there is zero help for those diagnosed in the ...

Subjects with Neurofibromatosis Type 2 (NF2) and progressive vestibular schwannoma (VS) will be treated with crizotinib administered orally. Crizotinib will be taken continuously until disease ...

The therapy has received Fast Track, Orphan Drug, and Rare Pediatric Disease designations from ... finding new therapies for individuals with neurofibromatosis and schwannomatosis.