The medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) are both integral components of the corticobasal ganglia–thalamic circuitry that regulates addiction-related behaviors. However ...

For example, they found that while mPFC-NAc synapses gradually increase in strength, the strength of mPFC-BLA synapses ...

They found that lowering dopamine-related proteins in the NAc of low-ranking mice made them take less METH. In contrast, when dopamine fibers in the mPFC of high-ranking mice were damaged, those ...

However, triggering the NAc had no effect on the animals’ waiting time. Interestingly, stimulating the mPFC enhanced the rodents’ ability to wait but only when they did not know the food’s ...

Chinese researchers have reported that slow rhythmic fluctuations in brain activity—theta oscillations in the medial prefrontal cortex (mPFC)–entorhinal cortex (EC) circuit—play an essential ...

These therapeutic effects are thought to involve modulation of the medial prefrontal cortex (mPFC), a brain region implicated in depression pathology. This study presents preliminary ...

The team worked with 121 participants, with 33 having focal damage to the mPFC, 17 with lesions elsewhere on the brain and 71 participants who had no brain damage but were of the same age.