The neural circuit linking the medial prefrontal cortex (mPFC) and the basolateral amygdala (BLA) has crucial roles in both the acquisition and the extinction of fear. However, the mechanism by ...

For example, they found that while mPFC-NAc synapses gradually increase in strength, the strength of mPFC-BLA synapses ...

“Our study suggests that double-projecting hippocampal neurons can facilitate synchronized neural activity in the mPFC and amygdala that is implicated in learned fear,” he said. “It is by modulating ...

In humans, the medial prefrontal cortex (mPFC) plays an important role in moderation of stress and also in social cognition, so the researchers theorized that the same may be true for mice.

These therapeutic effects are thought to involve modulation of the medial prefrontal cortex (mPFC), a brain region implicated in depression pathology. This study presents preliminary ...

The team then injected a virus into some of the mice that inserts a gene called GluR4 into mPFC neurons.GluR4 amplifies transmission of electrical signals – a key step in strengthening ...

The team worked with 121 participants, with 33 having focal damage to the mPFC, 17 with lesions elsewhere on the brain and 71 participants who had no brain damage but were of the same age.