Turning on the circuit that projected to the BLA caused more freezing responses, while activating the mPFC circuit increased tail shaking responses.

These therapeutic effects are thought to involve modulation of the medial prefrontal cortex (mPFC), a brain region implicated in depression pathology. This study presents preliminary ...

The team measured brain circuit function in the mPFC, also impaired by stress, by calculating the degree to which activity in cells was coordinated, a measure researchers term “functional ...