Using a new genetically engineered mouse model of esophagitis, the CUMC researchers have clarified critical cellular and molecular changes that occur during the development of Barrett's esophagus ...

Cells carrying mutations can out compete early tumors in the mouse esophagus, so they never make it into cancers, new research has shown. Normal human esophagus is a patchwork of cells containing ...

The esophagus is a hollow tubular organ whose wall comprises a mucosa or epithelium (with sparse lamina propria), submucosa (containing mucus-secreting glands and papillae), muscle (the proximal ...

Caption Mouse esophagus stem cells have the capacity to contribute to the repair of esophageal epithelium after induction of injury. Red areas are the injected stem cells that have migrated to the ...

The researchers set out to identify and characterize potential stem cells -- those with the ability to self renew -- in the esophagus to understand normal biology and how injured cells may one day be ...

"Essentially, we took more than 40,000 cells from mouse esophageal epithelium and used their individual gene-expression profiles to group them based on their commonality," she said. When they ...

Normal human esophagus carries a high number of mutations, but tumors are rare, due to mutant cells eliminating early tumors. Cells carrying mutations can out compete early tumours in the mouse ...

A small number of people with Barrett's esophagus eventually go on to develop EAC. Using a new genetically engineered mouse model of esophagitis, the CUMC researchers have clarified critical ...

These profiles can then be used to identify individual cell types within a complex tissue. “Essentially, we took more than 40,000 cells from mouse esophageal epithelium and used their individual ...