This is more advantageous than the previous indirect methods based on the expression of mitophagy markers as those genes are unspecific to the mitophagy induction." This dual fluorescent reporter ...

In this study, the researchers first conducted a whole-genome CRISPR-Cas9 screening to identify upstream regulators of PINK1-Parkin-mediated mitophagy. Among several hundreds of positive hits ...

Researchers have identified a new drug-like molecule that keeps mitochondria healthy via mitophagy, a process that removes and recycles damaged mitochondria in multicellular organisms. The ...

And to show how exercise induces mitophagy, Prof. Yan and team genetically modified mice to carry a gene that helps to report on the effects of physical activity. This gene is called pMitoTimer.

In this GEN webinar, our speaker John Renger, PhD, CSO at Cerevel Therapeutics, discusses preclinical markers used in assays relevant to neurodegenerative disease processes, including the ...

Researchers have revealed critical insights into how impaired mitochondrial dynamics and quality control mechanisms in skeletal muscle influence insulin sensitivity in patients with Type 2 ...

A new research paper was published on the cover of Aging, titled, "Mitophagy and cancer: role of BNIP3/BNIP3L as energetic drivers of stemness features, ATP production, proliferation, and cell ...