More information: Marta Mauro-Lizcano et al, Mitophagy and cancer: role of BNIP3/BNIP3L as energetic drivers of stemness features, ATP production, proliferation, and cell migration, Aging (2024 ...

our current work has provided a novel strategy to enrich for a sub-population of cancer cells, with high basal levels of mitophagy.” Mitophagy is a selective form of autophagy which permits the ...

In this review we will focus on the current understanding of the role of Parkin and mitophagy in the development, progression and treatment of cancer.

High BNIP3/BNIP3L transcriptional activity was accompanied by increases in i) BNIP3/BNIP3L protein levels, ii) lysosomal mass, and iii) basal mitophagy activity. Furthermore, cancer cells with ...

This process of "programmed cell death" often goes wrong in cancer. Damaged mitochondria can also undergo a form of "self-eating" termed mitophagy that prevents them from sending "death signals." ...

Dyfunctional mitophagy is known to be closely implicated in many diseases, including cancer, aging, and neurodegenerative diseases. At present, the molecular mechanisms of mitophagy have been ...

Mitophagy is the process of decommissioning and dismantling old mitochondria to make way for new and healthy replacements. However, in times of extreme need for energy, this process can be bypassed.

When damaged, they are removed through a recycling process called mitophagy, which is crucial for the function of long-lived cells, especially in the brain.

it is implicated in muscle wasting and sarcopenia and has a complex relationship with cancer progression. Even though interventions that restore mitophagy and facilitate the elimination of damaged ...

Dyfunctional mitophagy is known to be closely implicated in many diseases, including cancer, aging, and neurodegenerative diseases. At present, the molecular mechanisms of mitophagy have been ...