More information: Wanjie Wu et al, In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons, Nature Communications (2024). DOI: 10.1038/s41467-024-53218-0 ...

PDE-1905, offers high-resolution imaging of neuroinflammation by targeting a key enzyme inside microglia, the brain’s immune ...

A newly developed PET radiotracer has shown the ability to produce high-quality images of real-time brain inflammation, ...

Spatial Phenotypic Characterization of Microglia via CODEX Multiplexed Imaging Reveals Sub-Population-Level Relationships With Pathogenic Features in Alzheimer’s Disease Brains Bahareh Ajami ...

Three dimensional immunohistochemistry (3D-IHC) has transformed our ability to visualize the spatial arrangement of cells and ...

Remarkably, the researchers found that the vast majority of microglia were still alive even after imaging for 15 months. However, some microglia did vanish between sessions. Because the researchers ...

Selective microglia labeling and imaging also worked in live brains. The researchers observed cell-specific fluorescence when they incubated a whole mouse embryo with the probe, ...

Microglia abundance was positively correlated with both neuronal soma size and overall body size of the species, regardless of their evolutionary relationships. Since PNS microglia are required for ...

They then added microglia to brain organoids, tiny 3D structures of neurons that mimic some aspects of brain function, and transplanted these microglia-containing “mini-brains” into mice.