The receptor senses ApoE within amyloid plaques, drawing microglia to the aggregates. Once there, the microglia start clearing Aβ. “This paper presents a compelling connection between ApoE and VCAM1 ...

Microglia rapidly adopt an activated phenotype in response to brain injury and disease, which suggests that they could act as diagnostic markers of neurodegenerative disease onset or progression.

An international team of scientists has uncovered the vital role of microglia, the immune cells in the brain that acts as its dedicated defense team, in early human brain development. By ...

Microglia release molecular compounds that draw T cells into the brain from the blood and activate them; T cells release compounds that push microglia toward a more pro-inflammatory mode.

They then added microglia to brain organoids, tiny 3D structures of neurons that mimic some aspects of brain function, and transplanted these microglia-containing “mini-brains” into mice.

Microglia are the smallest member of the glia family and account for about 10% of all brain cells. The small cells have a central oval-shaped "body" from which slender tendril-like arms emerge.

Microglia abundance was positively correlated with both neuronal soma size and overall body size of the species, regardless of their evolutionary relationships. Since PNS microglia are required for ...

Microglia have been found to clear brain debris, such as amyloid plaques in Alzheimer’s disease (AD) and damaged myelin in multiple sclerosis (MS). The current study demonstrated that when a molecule ...

Sex-Specific Differences in Microglial Response “It is a fortuitous finding that has repercussions for what people are doing in the field, but also helps us understand microglia biology in a way ...

Using a microglia-depleting drug and AD mouse models, they identified that microglia have a neuroprotective effect in late disease. However, in early disease, microglia played a key role in spreading ...

Health Microglia: How the brain’s immune cells may be causing dementia. They fight invaders, clear debris and tend neural connections, but sometimes microglia go rogue.