Stroke remains one of the leading causes of death, disability, increased economic burden and decreased quality of life around the world. Current stroke therapies are time-limited and largely focused ...

Microglia, which are the brain’s immune system cells, are involved in everything – from brain development to protecting against diseases such as meningitis and Alzheimer’s.

The poor function of microglia, the brain's immune cells in individuals exposed to early life adversity (ELA) promotes aberrant responses to stress in adulthood that may be linked to mental ...

They then added microglia to brain organoids, tiny 3D structures of neurons that mimic some aspects of brain function, and transplanted these microglia-containing “mini-brains” into mice.

Microglia are the smallest member of the glia family and account for about 10% of all brain cells. The small cells have a central oval-shaped "body" from which slender tendril-like arms emerge.

Microglia straddle the fields of immunology and neuroscience. The cells begin in the yolk sac as part of the immune system, in the same cellular lineage as the macrophages of the blood.

Microglia have been found to clear brain debris, such as amyloid plaques in Alzheimer’s disease (AD) and damaged myelin in multiple sclerosis (MS). The current study demonstrated that when a molecule ...

Microglia abundance was positively correlated with both neuronal soma size and overall body size of the species, regardless of their evolutionary relationships. Since PNS microglia are required for ...

Health Microglia: How the brain’s immune cells may be causing dementia. They fight invaders, clear debris and tend neural connections, but sometimes microglia go rogue.

Using a microglia-depleting drug and AD mouse models, they identified that microglia have a neuroprotective effect in late disease. However, in early disease, microglia played a key role in spreading ...