The team reactivated a natural mechanism that shuts down with age to rejuvenate the thymus in very old mice. After treatment, the regenerated organ had a similar structure to that found in a young ...

Researchers have long assumed that a mouse has only a single thymus. This organ, located directly over the heart, generates immune system components called T cells that protect the body from many ...

In thymic epithelial cells, the research team upregulated a transcription factor called Forkhead box N1 (FOXN1), which had previously been implicated in age-related thymus shrinkage. Consequently, the ...

This image of a mouse thymus, made using light-sheet fluorescent microscopy, shows the three-dimensional structure of blood vessels in the organ. The thymus plays a primary role in training the immune ...

Raising hopes for cell-based therapies, UC San Francisco researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory. The researchers showed that, in ...

Cells from a mouse embryo were reprogrammed to look like thymus cells and then transplanted into a mouse. The cells formed a replacement organ with the same structure, complexity and function as a ...

They developed diarrhea and died within three weeks. Yet if thymus removal was postponed until the mice were a week or more old, they rarely developed these disorders—and never, if the operation ...

The discovery reveals the role of a growth factor and endothelial cells in thymus repair, and could have implications for chemotherapy and radiation patients’ recovery following treatment. The study’s ...

Scientists have discovered a way to extend the lives of lab mice by 40 percent and suggest that it could one day be used as a treatment to boost human lifespans. In a study published this week in ...