Mutations in PIK3CA and loss of PTEN contribute to its hyperactivation ... including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR).

Before delving into his experiences with the Mujahideen-e-Khalq (MEK), a terrorist organization known for its dogmatic indoctrination and isolated, tightly controlled environment, he said he wanted ...

Innovations in therapeutic strategies, coupled with a deeper understanding of breast cancer biology, will be essential for advancing personalized ...

One of these pathways is the PTEN / PI3K axis, a complex series of perfectly balanced chemical reactions. Mutations in the PTEN gene usually result in the overactivation of PI3K and the imbalance ...

Somatic uniparental disomy of PTEN in endothelial cells causes vascular malformations in patients with PTEN Hamartoma Tumor Syndrome. Cancer Discovery , 2025; DOI: 10.1158/2159-8290.CD-24-0807 ...