"We explored the possibility that not enough MBNL was expressed in the heart to restore normal function but found that expressing 4 or 10 times as much MBNL as normal mice did not rescue heart ...

Captured by this mutated DMPK RNA, MBNL proteins cannot carry out their function, which disrupts the RNA processing of hundreds of other genes, leading to the condition. "Loss of MBNL function is ...

The mutant DMPK gene produces an RNA containing a copy of the repeated building blocks that sequesters a family of RNA-binding proteins called muscleblind-like (MBNL). Captured by this mutated DMPK ...

An alteration in the causative gene, dystrophia myotonica protein kinase (DMPK), leads to a toxic messenger RNA (mRNA) that participates in the sequestration of muscleblind-like (MBNL) proteins ...

The mutant DMPK gene produces an RNA containing a copy of the repeated building blocks that sequesters a family of RNA-binding proteins called muscleblind-like (MBNL). Captured by this mutated ...