We identified a glycosidase from C. cellulans that 'uncaps' N-glycans modified by yeast-type mannose-Pi-6-mannose to generate mammalian-type N-glycans with a mannose-6-phosphate substitution.

The mannose 6-phosphate/IGF-2 receptor has been proposed to be a tumor suppressor gene on the basis of loss of heterozygosity and mutations in tumors from cancer patients. To test this hypothesis ...

Mannose enters cells using the same receptors as glucose. Once within the cell, it accumulates as mannose-6-phosphate. As this metabolite builds up, it slows down glucose metabolism.

Binding experiments demonstrated superior binding up to 40% of NAGLU-M6P to the cation independent mannose 6-phosphate receptor (CI-MPR) compared to NAGLU produced without S1S3.

Using our technology platform, we enhance mannose 6-phosphate content on lysosomal enzymes for both enzyme replacement and gene therapies, leading to improved enzyme uptake across target tissues.” ...

D-mannose is used to treat a rare disease called carbohydrate-deficient glycoprotein syndrome type 1b. This disease is passed down through families. It makes you lose protein through the intestines.

Mannose is a sugar, but it’s not something bought in the supermarket to sweeten your coffee or tea. It is made by the body itself from glucose or is converted into glucose – its molecules ...

Sanofi has developed a simpler way to create site-specific antibody-to-mannose-6-phosphate (M6P) conjugates that eliminates the need for enzyme remodeling. This more straightforward method makes ...

Mannose, a type of sugar, can greatly affect metabolism, weight gain, and the composition of gut bacteria in rodents. This result may lead to new treatments and prevention strategies for both ...

Research shows D-mannose is safe to take to prevent UTIs for up to six months, but the best way to do so isn't yet standardized. Some studies have found benefits from taking 1.5 grams of D-mannose ...

Mannose-binding lectin alleles were genotyped by means of a polymerase-chain-reaction assay in 91 Danish patients with SLE. Arterial and venous thromboses occurring after the diagnosis of SLE were ...