Blocking CKIα, CDK7, and CDK9 augments and synergistically stabilizes p53 and down regulates Myc and MCL1 promoting the rapid killing of leukemia cells as well as leukemic stem cells. Pre ...

Through studies of proteins that regulate p53, scientists at St. Jude ... such as upregulation of MYC or other oncogenes," explains corresponding author Richard Kriwacki, PhD, St. Jude Department ...

USPs such as USP22 and USP7 regulate key proteins like c-Myc and p53, influencing apoptosis in BC. Similarly, autophagy, a mechanism for cellular self-digestion, has a paradoxical role in BC ...