Mechanistically, MYC interacts with MAX and activates gene transcription by binding to E-box DNA elements, such as the canonical sequence CACGTG, in the regulatory regions of target genes. 5 MYC ...

The c-Myc gene is a transcription factor that is speculated to regulate the expression of 15% of all genes and is involved in one out of seven cancer-related casualties. [1–6] c-Myc activity is ...

Jidong Zhu, John Blenis, Junying Yuan, Activation of PI3K/Akt and MAPK Pathways Regulates Myc-Mediated Transcription by Phosphorylating and Promoting the Degradation of Mad1, Proceedings of the ...

MYC is dysregulated in nearly 70% of human cancers, where it influences a vast network of biological processes including cell cycle control, metabolism, apoptosis, angiogenesis, and immune evasion.

MYC is dysregulated in nearly 70% of human cancers, where it influences a vast network of biological processes including cell cycle control, metabolism, apoptosis, angiogenesis, and immune evasion.