Working with various human cancer cell lines, the group found that HIF-1α acts by displacing Myc, the transcriptional activator of two nuclear proteins, MSH2 and MSH6. In the absence of HIF-1α, Myc ...

Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was identified. Since that time, MYC research has been intense and the advances impressive. On reflection, it is ...