Since c-Myc has been well characterized for its role in a wide range of cancers, this finding may lead to more effective vaccines and improved immunotherapies for cancer. - here's the release ...

Already biotechnology companies are developing cancer drugs directed at MYC, but current efforts involve drugs that would block all MYC function. Understanding the specific targets of MYC and ...

A gene known as Myc is linked to cancer growth, but has long been considered “undruggable." Now, researchers at Vanderbilt University have found a way to bypass it and shut down a protein that ...

Male mice lacking the MLX binding partner and fellow MYC network member MondoA were also infertile, though in this case sperm were generated at appropriate numbers but were nonmotile, suggesting at ...

Lausanne – c-myc, a gene commonly involved in cancer onset, has been found to have a role in the immune system's normal function according to a study published today in Blood.

But MYC is often extremely overactive in aggressive tumors, where its function can be likened to that of an accelerator pedal that has got stuck. The mechanisms by which MYC functions in the cell ...

Various published studies have used genomic amplication, immunohistochemical staining, mRNA expression, or MYC-regulated gene signature expression to identify MYC-elevated tumors in humans. A major ...

MYC drives the development of a wide range of cancers by enhancing the growth and proliferation of tumor cells. This is mainly due to MYC's function as a transcription factor controlling the ...

How the proto-oncogene c-Myc balances the processes of stem-cell self-renewal, proliferation and differentiation in adult tissues is largely unknown. We explored c-Myc’s transcriptional roles at ...

But MYC is often extremely overactive in aggressive tumours, where its function can be likened to that of an accelerator pedal that has got stuck. The mechanisms by which MYC functions in the cell ...

The Myc family of transcription factors includes three highly conserved genes, MYC, MYCN and MYCL1 that have similar biological functions (reviewed in Refs 1, 2).

Cancer Gene MYC Emerging As Key Research Target Date: July 12, 2004 Source: The Wistar Institute Summary: First discovered twenty years ago, the cancer gene MYC is the most overexpressed oncogene ...