T cells are activated in a dual-signal process: the first signal binds the peptide-MHC complex on the surface of the APC to the T-cell receptor (TCR); the second signal involves the interaction of ...

We have developed a system that mimics the physiological interactions among T cells and APC. We use artificial antigen-presenting cells (aAPC), composed of a liposome, in which MHC class II ...

Antigen processing and presentation is the process by which protein antigen is ingested by an antigen-presenting cell (APC), partially ... molecule such as MHC class I or MHC class II, for ...

T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human ...

The Trial in Progress poster includes an overview and study design of the TACTI-004 Phase III evaluating the Company’s MHC Class II agonist, eftilagimod alfa (efti) in combination with MSD’s (Merck & ...