Successful engraftment of hematopoietic stem cells from unrelated donors is influenced by disparities between the donor and recipient for HLA-A, B, and C alleles. Disparities between HLA sequence ...

However, accurately assigning HLA alleles or loci to the defense ... among the many functionally related loci in the major-histocompatibility-complex (MHC) genes also make it difficult to identify ...

Certain MHC alleles are associated with an increased risk of autoimmune disease such as Hodgkin’s lymphoma and multiple sclerosis. Another function of the major histocompatibility complex is ...

Thousands of variants There are thousands of different variants of the human MHC-I proteins, produced by different “alleles” of the MHC-I genes. The extreme variability of MHC-I proteins accounts for ...

Depending on which MHC-I variants or alleles are present, the body may mount a successful immune response to SARS CoV-2, or may fail to do so, leaving the body vulnerable. In new research ...

Epitopes were previously identified in SARS and are 100 percent conserved in SARS-CoV-2. Refer to Table 1 for the current available MHC alleles. If the requested MHC allele is not in the table or if ...

Other evidence for balancing selection was also found, including a gene phylogeny for MHC alleles from Magellanic, Humboldt, and Galapagos penguins. This analysis, akin to developing a "family ...

These are intriguing results. But there is also some data for selective positive assortative mating; e.g., females being attracted to the smell of those who have their father's MHC alleles! So though ...

Depending on which MHC-I variants or alleles are present, the body may mount a successful immune response to SARS CoV-2, or may fail to do so, leaving the body vulnerable. In new research ...