The existence of several p53 isoforms in elephants with different capacities to interact with MDM2 offers an exciting new approach to shed new light on p53's tumor suppressor activity.' ...

An x-ray crystallographic structure of the Numb domain that binds to Mdm2, with the crucial stretch of 11 amino acids--only present in Numb isoforms 1 and 2--shown in red.

MDM2 amplification occurs in 3.5% to 7.0% of human cancers, although no specific copy-number threshold for the alteration has been determined. In DDLPS, intimal sarcomas, and certain other tumors ...

As a key survival signaling pathway, the MDM2/p53 axis is widely involved in the development of many tumors. Preclinical and clinical trials provide evidence to support the notion that inhibition ...