b Patients taking 25-50 mg once daily should take one supplemental pregabalin dose of 50 or 75 mg after hemodialysis. c Patients taking 75 mg once daily should take one supplemental pregabalin ...

Conversion from Lyrica capsules, oral soln: see full labeling. For all: renal impairment (CrCl 30–60mL/min): reduce dose (see full labeling); (CrCl <30mL/min or hemodialysis): dose with Lyrica.

Pregabalin binds with high affinity to the alpha2 ... Underlying respiratory depression; monitor and consider initiating at a low dose. CHF (w. NYHA Class III/IV status). Ocular conditions.

Richard B. Silverman’s 1988 discovery led to the creation of blockbuster drug Lyrica. The initial research began in 1988 in Northwestern professor Richard B. Silverman’s chemistry lab. Silverman and a ...