The prevalence of congenital LQTS is reportedly 1 in 2000. 1 In this review, we focus on the advances in our understanding of the genetics of LQTS. In the presence of a corrected QT interval (QTc ...

Although a normal QT interval imparts a much lower risk of life-threatening events, it does not preclude a patient from nevertheless harbouring a potentially lethal LQTS-causing genetic mutation.

LQTS may be either congenital or acquired. The genetic epidemiology of both forms can vary with subpopulation depending on the allele, but as a whole, LQTS appears in every corner of the globe.

Genetic blood tests usually are suggested for family members of people who have LQTS as well. These tests are not always accurate and may miss the diagnosis. In addition, some people may test ...

While fully respecting these guidelines and participating in the Bethesda conference guidelines as a coauthor (MJA), we have embraced the tenets of self-determination and patient/family autonomy in ...

Researchers at the University of Rochester Medical Center recently discovered a genetic link between Long QT Syndrome (LQTS), a rare cardiac rhythm disease, and an increased risk for seizures.

LQTS is a genetic condition in the majority of cases and occurs from birth till death. There are no cures for this condition and no therapy can restore a normal QT interval. However, therapy may ...

“In this molecular genetic evaluation of 91 cases of intrauterine fetal death, missense mutations associated with LQTS susceptibility were discovered in three cases (3.3%), and overall, genetic ...

Long QT syndrome (LQTS) is the prototypic cardiac channelopathy underscored by profound genetic and phenotypic heterogeneity. In 1991, the first LQTS chromosome locus was identified and ...

Although patterns may suggest a specific genotype of the long-QT syndrome, 5 many variants have been described. 37 Genetic testing for the long-QT syndrome is most useful in two settings.

Fainting or syncope is the most common symptom of LQTS, affecting 50% of those with a genetic variant. It often occurs during exercise or times of high emotions. Sudden death is the first sign of ...