Long QT syndrome (LQTS) is the prototypic cardiac channelopathy underscored by profound genetic and phenotypic heterogeneity. In 1991, the first LQTS chromosome locus was identified and ...

Shared decision-making forms an increasingly important part of the expert consultation for athletes with genetic heart ...

Although a normal QT interval imparts a much lower risk of life-threatening events, it does not preclude a patient from nevertheless harbouring a potentially lethal LQTS-causing genetic mutation.

Long QT syndrome (LQTS) is potentially lethal if left untreated. Accurate diagnosis is, therefore, vital. Patients with LQTS have impaired adaptation of the QT interval in response to changes in ...

Familial LQTS and familial HCM are genetic disorders caused by gene mutations inherited in an autosomal dominant fashion. Children, siblings, and parents of affected patients have 50% risk of ...

Since the 1990s, genetic testing in cardiology practice ... ion channel subunits are responsible for 75% of cases of long QT syndrome (LQTS), an inherited heart rhythm problem that may be ...

For instance, people identified with a genetic predisposition to long QT syndrome can be monitored more closely for signs of arrhythmia while those with a family history of hypertrophic ...

Current major projects in the lab focus on the molecular basis of inherited arrhythmia syndromes like catecholaminergic polymorphic ventricular tachycardia (CPVT), congenital long QT syndrome (LQTS ..

Inherited mutations in the hERG channel gene, or drug-induced inhibition of channel function lead to inherited or acquired Long QT syndrome (LQTS ... of how channel phenotype may be influenced by ...

Inherited mutations in the hERG channel gene, or drug-induced inhibition of channel function lead to inherited or acquired Long QT syndrome (LQTS ... of how channel phenotype may be influenced by ...