The bacterial membrane-anchored cell-wall precursor Lipid II can be considered an Achilles' heel of bacteria, as it is an essential component of bacterial cell walls and is a relatively easily ...

In the randomized, open-label Atorvastatin Comparative Cholesterol Efficiency and Safety Study (ACCESS), Andrews et al. [8] compared rates of achieving ATP II LDL-C goals in 3916 ...

However, a detailed structural analysis of clovibactin could only uncover how it manages to bind PPi of lipid II tightly and selectively. Another striking feature of clovibactin was its ...

Previous studies suggested a conventional model where plectasin binds to a molecule called Lipid II, crucial for bacterial cell wall synthesis, akin to a key fitting into a lock. The new study ...

Previous studies suggested a conventional model where plectasin binds to a molecule called Lipid II, crucial for bacterial cell wall synthesis, akin to a key fitting into a lock. The new study ...

“The only difference is nisin has two rings that bind to lipid II, and these rings are different from what epilancin has.” The researchers first tested to see whether epilancin could interfere ...

They published their results “Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides” in Nature Communications. Using advanced bioinformatics ...