Leptin helps hungry mice choose sex over food Date: February 23, 2023 Source: Cell Press Summary: To eat or to mate -- that is the question (and the answer is: moderately hungry mice choose to mate).

Zeng et al. 1 report that, in mice, leptin acts in the brain, triggering signals that activate ganglionic neurons of the sympathetic nervous system whose projections (called axons) wrap around fat ...

Mouse study published in Science Translational Medicine suggests an old approach to obesity, the leptin hormone, could improve efficacy of GLP-1 drugs. Skip to Main Content.

"Before our research, the cause of obesity in diet-induced obese mice was unknown, leaving a critical gap in our ...

When the so-called fat-controlling hormone leptin was first discovered, scientists predicted it would be the basis for a bonanza of new obesity-fighting drugs. That was 15 years ago. Today ...

The results were striking: "Obese mice fed a high-fat diet and treated with the mTOR inhibitor rapamycin lost significant amounts of weight, which -- similar to leptin treatment in leptin ...

Some studies in mice have found evidence that leptin can blunt the effects of a common estrogen-positive breast cancer drug. Future drug therapies may target high leptin levels or leptin resistance.

They had good reason to think leptin might work as a weight loss tool. It all started with a mouse. For decades, scientists were curious as to why a certain breed of mouse kept overeating, lying ...

However, leptin stimulation was not able to override the stronger hunger of chronically food restricted mice, whose appetites were unreduced and priorities unmoved by leptin activation.

The results were striking: “Obese mice fed a high-fat diet and treated with the mTOR inhibitor rapamycin lost significant amounts of weight, which—similar to leptin treatment in leptin ...

Leptin stimulation had little effect on the behavior of sated mice, who were generally more interested in socializing than eating, but when the researchers activated the leptin receptor neurons of ...